EPA Releases Final Peer Review Report on 1-Bromopropane
EPA’s final peer review report on 1-bromopropane (1-BP) became available from the agency’s primary scientific peer-review mechanism, the Chemical Safety Advisory Committee (CSAC), on Aug. 22. The committee, which provides independent expert assessment of chemical and chemical-related matters facing EPA, met in May to review EPA’s draft risk assessment for 1-BP. CSAC’s report states that the draft risk assessment’s conceptual model “appropriately considers worker exposures and consumer uses, with the majority of exposure occurring via inhalation.”
EPA’s draft risk assessment for 1-BP, also known as n-propyl bromide, indicates health risks for workers with repeated and chronic exposures to the chemical, including neurotoxicity; kidney, liver, and reproductive toxicity; and lung cancer. The draft risk assessment estimates that as many as 48,900 workers and occupational non-users are potentially exposed to 1-BP from use in spray adhesives, dry cleaning, vapor degreasing, and aerosol degreasing.
CSAC’s peer review report concludes that EPA’s draft risk assessment “appropriately uses a high-end estimate for worker exposure.” To improve the agency’s analysis of occupational exposures, the committee encourages EPA to consider that many dry-cleaning facilities are family-owned and operated. CSAC recommends that EPA expand the scenarios for worker hours in dry cleaners to include a wider range—for example, 4, 6, 8, and 12 hours. Further, the committee urges EPA to consider estimating potential exposures to 1-BP in children who could be helping out or waiting for their parents to finish work at dry-cleaning facilities. The peer review report also concludes that it’s appropriate for EPA to assume that the dry-cleaning machines in its exposure scenarios are older models because “family-owned and operated facilities may not have the resources to purchase newer equipment.”
The full peer review report is available on EPA’s website. Supporting materials for the CSAC meeting are available via